Strangers in Paradise, by Terry Moore.
Strangers In Paradise (SIP) is the story of three friends, Francine, Katchoo and David and the people they fall in and out of love with.
It's a tale of dark pasts and hopeful futures, double-crosses and true friendship, love and hate.
In other words: it's a story of real life, kicked up a notch.
The highly acclaimed ongoing comic book series, Strangers In Paradise, was created by Terry Moore in 1993 and the continuing story is published every six weeks. SIP has been awarded numerous industry awards including the 2003 Inkpot Award for Outstanding Achievement in Comic Arts, a 2002 YALSA/ALA selection for Popular Paperbacks for Young Adults, the GLAAD Media Award for Best Comic Book in 2000, and the 1996 Will Eisner Comic Industry Award for Best Serialized Story.
A long running series about three friends. No super-heroes, no zombies, no magic, other than the magic of love. It's won several awards, has multiple collections and should be easily available at your local comics shop as well as your local bookstore.