Abbie an' Slats (1937-1971) originally by Al Capp and Raeburn van Buren (USA)
Abie the Agent (1914-1940) by Harry Hershfield (USA)
The Academia Waltz (1978-1979) by Berke Breathed (USA)
According to Guinness (1975-1990) by Norris McWhirter and Ross McWhirter (USA)
A Couple of Guys by Dave Brousseau (1996-present) (USA)
A Man Called Horace (Daily Record (Scotland) newspaper) - by Roger Kettle & Andrew Christine (90s - 2000s) (UK)
Ad Libs (1958-1975) by Jim Whiting and Larry Hurb, and later Len Bruh and Joe Daley (USA)
Adam@home (1984- ), first titled Adam, by Brian Basset (USA)
Adamson (1920-1945) by Oscar Jacobsson (Sweden)
The Adventures of Patsy (1935-1954) by Mel Graff, and later Frank Reilly, Charles Raab, Rich Hall, and Bill Dyer (USA)
The Adventures of Tintin (1929-1944) by Hergé (Georges Rémi) (Belgium)
Agatha Crumm (1977-1996) originally by Bill Hoest, and later John Reiner, and Bunny Hoest (USA)
Aggie Mack (1946-1965) by Hal Rasmussen and Roy L. Fox (USA)
Agnes (1999- ) by Tony Cochran (USA)
Air Hawk and the Flying Doctors (1959-1986) by John Dixon (Australia)
Akwas (1964-1972) by Mike Roy (USA)
Al Khan (2008- ) by Tarek Shahin (Egypt)
Alec the Great (1931-1969) by Edwina
Alex (1987- ) by Charles Peattie and Russell Taylor (UK)
Alex in Wonderland (1976-1986) by Bob Cordray
Alexander Smart, Esq. (1930-1943) by A. C. Fera and later Doc Winner
Alfredo (see Pepe)
All in a Lifetime (1936-1961) by Frank H. Beck
All in Sport (1952-1970) by Chet Adams (USA)
All in the Family (1980-1995) by Bill Murray
Alley Oop (1932- ) originally by V. T. Hamlin (USA)
An Altar Boy Named Speck (1953-1973) by Tut LeBlanc and later Margaret Ahern
Always Belittlin' (1930-1940) by Percy Crosby (USA)
The Amazing Spider-Man (1977- ) by Stan Lee and John Romita, Jr. (USA)
The Ambassador (1933-1934) by Otto Soglow
Amber Waves (2000- ) by Dave T. Phipps
Les Amours célèbres (1950-1970) by Paul Gordeaux (France)
A. Mutt (see Mutt and Jeff)
Amy (1962-1991) originally by Harry Mace (USA)
And Her Name Was Maud (1904-1932) by Frederick Burr Opper (USA)
Andy Capp (1957- ) originally by Reg Smythe (UK)
Angel (1954-1963) by Mel Casson
The Angriest Dog in the World (1983-1992) by David Lynch (USA)
Angus Og (?-1986) by Ewen Bain (Scotland)
Animal Antics (1947-1961) by Ed Nofziger (USA)
Animal Crackers (1968- ) by Rog Bollen and later Fred Wagner (USA)
Animalogic (1967-1978) by Ed Nofziger (USA)
Annie (see Little Orphan Annie)
Antiques: The Comic Strip (2006- ) by J. C. Vaughn, Brendon Fraim and Brian Fraim (USA)
Apartment 3-G (1961- ) originally by Nicholas P. Dallis and Alex Kotzky (USA)
Aphrodite (1985-1995) by various creators
A. Piker Clerk (1904) by Clare Briggs (USA)
Apple Pie (1972-1995) by Gus Wood and R. David Boyd
Archie (1947- ) originally by Bob Montana (USA)
Arctic Circle (2007- ) by Alex Hallatt (New Zealand)
The Argyle Sweater (2008- ) by Scott Hilburn (USA)
Arlo and Janis (1985- ) by Jimmy Johnson (USA)
Arnie (1973-1995) by Arnie Stockholm and later Muir
Arnold (1983-1987) by Kevin McCormick (USA)
Art's Gallery (1965-1977) by Art Finley (USA)
Arty Facts (1983-1995) by Ray Fisher
As You Were (1972-1995) by Jim Baker (USA)
Ask Shagg (1979- ) by Peter Guren (USA)
Assignment: Top Secret (1981-1993) by Bill Barry and later Fred Hall
Assorted Nuts by Nick Barrameda (Philippines)
Asterix and Obelix (1977) by René Goscinny and Albert Uderzo (USA reprint of French album stories edited into comic strip form).
At the Zü (1995-1998) by Ron Ruelle (USA)
Aunt Tenna by Bil Keane (USA)
The Avridge Farm (1987-2005) by Jeff Wilson (Canada)
AXA (1978-1986) by Enrique Badia Romero and Donne Avenell (UK)
Babe 'n' Horace (1939-1970) by Edgar E. Martin and later Les Carroll (USA)
Baby Blues (1990- ) by Rick Kirkman and Jerry Scott (USA)
Baby Mine (1930-1939)
Back Home (1986-1995) by Hormer Box
Bachelor Party (2002-2003) by Adam Miller (USA)
Backbench (-) by Graham Harrop (Canada)
Bad Reporter (2003- ) by Don Asmussen (USA)
Baldo (2000- ) by Hector Cantú and Carlos Castellanos (USA)
Ballard Street (1991- ) by Jerry Van Amerongen
Barnaby (1942-1952, 1960-1962) originally by Crockett Johnson (USA)
Barnacle & His Friends (1983-1992) by Alex Moore
Barney Baxter (1935-1950) by Frank Miller (USA)
Barney Google and Snuffy Smith (1919- ) and (1934- ) respectively, Billy De Beck for both, and later Fred Lasswell for Snuffy (USA)
Baron Bean (1916-1919) by George Herriman (USA)
Basil (1974-1980) by Gerry Lants (Australia)
Bat Masterson (1959-1970) by Ed Herron and Nostrand
Batman (1989-1991) by Max Allan Collins and Marshall Rogers (USA)
Batman and Robin (1943-1974) originally by Bob Kane (USA)
B.C. (1958- ) by Johnny Hart (USA)
Bear Creek Folks by C.M. Payne (USA)
Beattie Blvd. (1986- ), first titled SNAFU, by Bruce Beattie (USA)
Beau Peep (1978-) by Roger Kettle and Andrew Christine (UK)
Beelzebub Jones (1937-1945) by Hugh McClelland (UK)
Beetle Bailey (1950- ) by Mort